Oriental Journal of Medicine and Pharmacology

DIABETES INSIPIDUS: MODERN ASPECTS OF PHARMACOTHERAPY

Munisa Saifitdinkhujaeva, Zafar Sanoev — Mon, 30 Dec 2024 00:00:00 +0000

Diabetes insipidus currently affects 1 in 25,000 people. Diabetes insipidus, both central and nephrogenic, can be hereditary or acquired. Acquired forms of DI are much more common than hereditary forms, which account for only about 6–10% of DI cases. Primary polydipsia is most often associated with psychiatric disorders such as schizophrenia, schizoaffective or bipolar disorders, but has also been described in patients with anxiety and anorexia or other addictive disorders . In most patients with central DI, osmoregulated thirst is intact, and therefore oral fluid intake accurately compensates for urinary and insensible water losses. Therefore, even without treatment, patients are usually eunatremic. Treatment is usually initiated with desmopressin. The main complication of desmopressin therapy is hyponatremia. A retrospective review found that 27% of patients with central DI have mild hyponatremia on routine electrolyte testing, and 15% develop more severe hyponatremia with long-term follow-up.

PECULIARITIES OF ELECTRONEUROMYOGRAPHIC PARAMETERS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS DEPENDING ON BODY MASS INDEX

Shavkat Kabilov, Rano Abdujamilova, Janna Nazarova, Lola Mamadinova — Thu, 19 Dec 2024 00:00:00 +0000

Despite advances in diagnosis and treatment, complications of diabetes mellitus (DM) remain the most important problem for patients and their families. Microvasculature damage can lead to blindness, renal failure and amputation.

FREQUENCY OF VARIOUS NEUROLOGICAL SYNDROMES IN PRIMARY HYPOTHYROIDISM AMONG RESIDENTS OF THE ARAL SEA REGION

N. Artikov, M. A Bakhadirova — Sun, 22 Dec 2024 00:00:00 +0000

This article analyzes the structure of neurological syndromes associated with primary hypothyroidism, with cognitive impairments and polyneuropathies being the most common. The study results demonstrate that the severity of syndromes correlates with TSH levels and TPO antibodies. Additionally, the age of patients significantly influences the distribution and severity of neurological complications, highlighting the need for an individualized approach to diagnosis and treatment.

GENDER-RELATED CHARACTERISTICS OF PATIENTS WITH TRANSIENT ISCHEMIC ATTACKS

N. Khodjayeva, N. Aliyeva — Sat, 09 Nov 2024 00:00:00 +0000

This article analyzes the clinical and neurological features of transient ischemic attacks (TIA). The study results reveal TIA risk factors and their role in stroke development. Key patient characteristics and diagnostic methods are highlighted.