This study investigates the differences in intestinal microflora and inflammatory indicators between patients with and without COVID-19, focusing on those with pathological changes in the gastrointestinal (GI) system. The COVID-19 pandemic has highlighted the importance of understanding how the virus affects various bodily systems, including the GI tract. Our comparative analysis included patients diagnosed with COVID-19 and experiencing GI symptoms, alongside a control group of individuals without COVID-19. We assessed the composition of intestinal microflora and measured specific inflammatory markers. The results indicate significant alterations in the gut microbiome and elevated inflammatory indicators in COVID-19 patients, suggesting a potential link between the virus and GI pathology. These findings could contribute to better understanding and managing GI complications in COVID-19 patients.