Metabolic syndrome (MS) prevalence among young adults (18–30 years) ranges from 4.8% to 7.0%, with low HDL cholesterol being the most common component. Obesity and related metabolic disturbances continue to rise globally, making MS a major public health concern in youth. Melatonin, a potent antioxidant and chronobiotic, regulates circadian rhythms, glucose and lipid metabolism, and inflammation. Reduced endogenous melatonin levels in MS patients are associated with metabolic dysfunction and endothelial impairment.

Metabolic syndrome, Young adults, Melatonin, 6-sulfatoxymelatonin, Circadian rhythm, Insulin resistance, Dyslipidemia, Hypertension.

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