CLINICAL AND NEUROLOGICAL CHARACTERISTICS OF PATIENTS WITH ATHEROTHROMBOTIC LESIONS OF EXTRACRANIAL ARTERIES
Abstract
This article analyzes the clinical and neurological characteristics of patients with atherothrombotic lesions of the extracranial arteries of the brain. The study was conducted in Nukus from 2022 to 2024 and included clinical data from 128 elderly patients. According to the results, arterial hypertension and dyslipidemia were the leading risk factors, identified in more than 75% of patients in all clinical groups. In patients with combined stenosis of the internal carotid and vertebral arteries (Group III), the clinical symptoms were more severe, dominated by headache, dizziness, tinnitus, memory decline, and fatigue. Among neurological disorders, pyramidal signs, asymmetry of muscle tone, and coordination disturbances were common. The results of the study confirm the progressive development of vascular system damage in cases of combined and multifocal stenosis and indicate the necessity of early diagnosis and comprehensive preventive measures.
Keywords
extracranial arteries, atherothrombosis, ischemic stroke, stenosis, internal carotid artery, vertebral artery, hypertension, dyslipidemia, neurological symptoms, cerebrovascular pathology.How to Cite
References
Feigin V.L., et al. Global and regional burden of stroke during 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Neurol. 2021;20(10):795–820.
Sacco R.L., et al. Guidelines for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack. Stroke. 2021;52:e364–e467.
North American Symptomatic Carotid Endarterectomy Trial Collaborators. Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. N Engl J Med. 1991;325:445–453.
de Weerd M., et al. Prevalence of asymptomatic carotid artery stenosis according to age and sex: systematic review and metaregression analysis. Stroke. 2009;40(4):1105–1113.
Abbott A.L. Medical (nonsurgical) intervention alone is now best for prevention of stroke associated with asymptomatic severe carotid stenosis. Stroke. 2009;40(10):e573–e583.
Nicolaides A.N., et al. Asymptomatic internal carotid artery stenosis and cerebrovascular risk stratification. J Vasc Surg. 2010;52:1486–1496.
Gupta A., et al. Carotid plaque MRI and stroke risk: a systematic review and meta-analysis. Stroke. 2013;44:3071–3077.
Markus H.S., et al. Cerebrovascular reactivity and dynamic autoregulation in patients with carotid stenosis. Stroke. 2001;32:2616–2621.
Kernan W.N., et al. Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack. Stroke. 2014;45:2160–2236.
Rothwell P.M., et al. Population-based study of event-rate, incidence, case fatality, and mortality for all acute vascular events in all arterial territories. Lancet. 2005;366:1773–1783.
License
Copyright (c) 2025 Nargiza Abdullayeva, Sardorbek Yuldashev
This work is licensed under a Creative Commons Attribution 4.0 International License.
