BIOLOGICAL ACTIVITY OF DITERPENE ALKALOIDS OF THE GENUS DELPHINIUM (Literature review)
Abstract
Plants of the genus Delphinium have long been used in the Tibetan region due to their medicinal properties, and their analgesic, antibacterial, anxiolytic, antidepressant and anticancer activity is due to their main biologically active compounds, alkaloids, flavonoids and sterols. The review of this article summarized the compounds and pharmacological effects of the genus Delphinium and serves as a source of information necessary for further research.
Keywords
Delphinium, alkaloid, diterpene, pharmacological activity, arrhythmia, antidepressant and anticonvulsant activity.How to Cite
References
Wang W. C., Michael J. W. (2001). Flora of China Editorial Committee of Chinese Academy of Sciences, Beijing, China, Flora of China, pp. 223–274.
Flora of China Editorial Committee of Chinese Academy of Sciences, (1979). Flora Reipublicae Popularis Sinicae, Flora of China Editorial Committee of Chinese Academy of Sciences, Beijing, China, p. 326.
Wang F. P., Chen Q. H., Liu X. Y. (2010). “Diterpenoid alkaloids,” Natural Product Reports, vol. 27, №4, p. 529.
Sanoev Z. I., Khamroev T. T., Djaxangirov F. N., Sadikov A. Z., & Sagdullaev S. S. (2021). Antiarrhythmic activity of N-deacety lappaconitine when administered orally. Annals of the Romanian Society for Cell Biology, 2339-2346.
Ҳамроев Т. Т., Саноев З. И., Абдиназаров И. Т., Азизова М. А., Рахимбоев С. Д., & Рашидов С. З. (2021). Экспериментальное исследование N-дезацетилаппаконитина (N-DAL) фармакодинамические и противофибрилляторные эффекты. Life Sciences and Agriculture, (3-4 (7-8)), 11-16.
Dzhakhangirov FN, Sultankhodzhaev MN, Tashkhodzhaev B, Salimov BT. (1997) Diterpenoid alkaloids as a new class of antiarrthythmic agents. Structure-activity relationship. Chemistry of Natural Compounds, 33, 190–202.
Ameri A. (1998) The effects of aconitum alkaloids on the central nervous system. Progress in Neurobiology, 56, 211–235.
Khamroev T. T., Sanoev Z. I., Rakhimboev S. D., Abdinazarov I. T., & Rashidov S. Z. (2021). Effect of anti-arrhythmic substance N – dezacetyllapoconitin on the central nervous system. ISJ Theoretical &Applied Science, 07 (99), 153-157.
Khamroev T.T., Sanoev Z.I., Abdinazarov I.T., Rakhimboev S.D., Rashidov S.Z. (2021). Study Of The General Pharmacological Properties Of A New Antiarrhythmic N-Deacetyllappaconitine With Oral Administration. The American Journal of Medical Sciences and Pharmaceutical Research, 3(03), 60-64. IF 5.64. https://doi.org/10.37547/TAJMSPR/Volume03Issue03-08
Zakhidova L.T., Saidkhodjaeva D.M., Khamroev T.T., Sanoev Z.I., Tukhtasheva V.F., Rakhmanova H.A. (2021). Toxicological Characteristics Of N-Deacetyllappaconitine Under Chronic Administration In White Rats. The American Journal of Applied Sciences, 3(03), 3441. IF 5.634, https://doi.org/10.37547/tajas/Volume03Issue03-06
Sanoev Z. I., Khamroev T. T., Abdinazarov I. T., Sadikov A. Z., Rakhimboev S. D., & Rashidov S. Z. (2022). Study of N-deacetylappaconitine (N-DAL) anticonvulsant action. Oriental Journal of Medicine and Pharmacology, 2(02), 29-37.
Rakhimova S.K., Kurbanov U.K., Mezhlumyan L.G. et al. Proteins from the Aerial Part of Delphinium leptocarpum and Their Biological Activity. Chem Nat Compd 59, 750–753 (2023). https://doi.org/10.1007/s10600-023-04101-9
Panter KE, Manners GD, Stegelmeier BL, Lee S, Gardner DR, Ralphs MH, Pfister JA, James LF. (2002) Larkspur poisoning: toxicology and alkaloid structure-activity relationships. Biochemical Systematics and Ecology, 30, 113–128
Ren S. Y., Qiansiri G. L., Wang H. Y. et al., (2009). “Extraction and antibacterial test of alkaloid from root of Delphinium grandiflorum,” Journal of Dalian Polytechnic University, vol. 28, № 4, pp. 248–250.
Zaheer I., Rahman S. Z., Khan R. A. et al., (2018). “Evaluation of analgesic activity of extracts of Delphinium denudatum in animal models: a dose dependent pre-clinical trial (Article),” Journal of Clinical and Diagnostic Research, vol. 12, №12, pp. FC1–FC4.
Nesterova Y. V., Povetieva T. N., Nagornyak Y. G., Vetoshkina T. V., and Andreeva T. I. (2009). “Correction of adjuvant arthritis with delphinium extracts and alkaloids,” Bulletin of Experimental Biology and Medicine, vol. 147, №6, pp. 711– 714.
Suslov G. S., Jia Z. P., Qiao S. Z. et al., (2010). “Experimental studies on haemostasis and analgesic effect of Delphinium grandiflorum L. var. leiocarpum,” Chinese Journal of Hospital Pharmacy, vol. 30, №11, pp. 898–900.
Nesterova Y. V., Poveteva T. N., Nagornyak Y. G., Andreeva T. I., and Suslov N. I. (2008). “Effects of bioactive substances from tall delphinium on the development of acute inflammation of different genesis,” Bulletin of Experimental Biology and Medicine, vol. 145, №6, pp. 724–727.
Andreeva L. and Liu Y. J. (2011). “Study of Delphinium grandiflorum flavonoids on inhibition of inflammation in mice,” China Modern Medcine, vol. 18, № 32, p. 14-59.
Ebrahimzadeh M. A., Nabavi S. F., Nabavi S. M. et al., (2010). “Biological and pharmacological effects of Delphinium elbursense,” African Journal of Biotechnology, vol. 9, №34, pp. 5548–5555.
Mohammad A., Kumar G. A., and Najam A. K. (2017). “In vivo psychopharmacological investigation of Delphinium denudatum and Amaranthus spinosus extracts on Wistar rats,” Basic and Clinical Neuroscience Journal, vol. 8, № 6, pp. 503–512.
Zheng S. J., Xu C., Yang J. et al., (2017). “In vitro anticancer screening of Tibetan medicines,” Journal of Huazhong Normal University (Natural Sciences), vol. 51, №3, pp. 328–334.
Zahoor M, Nisar ud Din, Khan N. (2014). Antibacterial activities of methanolic extracts of aerial parts of Delphinium uncinatum Hook’s and Thoms. Sci Technol Dev.;33(2):77-9.
Jeppesen AS, Soelberg J, Jäger AK. (2012). Antibacterial and COX-1 inhibitory effect of medicinal plants from the Pamir Mountains, Afghanistan. Plants (Basel).;1(2):74-81. doi: 10.3390/plants1020074.
Sanoev Z. I., Khamroev T. T., Abdinazarov I. T., Rashidov S. Z., & Rakhimboev S. D. (2021). Evaluation of Anticonvulsant Activity of Allapinine and N-Deacetylappaconitine in Experimental Animals. Journal Healthcare Treatment Development, 1(02), 12–19. https://doi.org/10.55529/jhtd.12.12.19
Salehi, A., Ghanadian, M., Zolfaghari, B., Jassbi, A. R., Fattahian, M., Reisi, P., Csupor, D., Khan, I. A., & Ali, Z. (2023). Neuropharmacological Potential of Diterpenoid Alkaloids. Pharmaceuticals (Basel, Switzerland), 16(5), 747. https://doi.org/10.3390/ph16050747
Turabekova, M. A., Rasulev, B. F., Levkovich, M. G., Abdullaev, N. D., & Leszczynski, J. (2008). Aconitum and Delphinium sp. alkaloids as antagonist modulators of voltage-gated Na+ channels. AM1/DFT electronic structure investigations and QSAR studies. Computational biology and chemistry, 32(2), 88–101. https://doi.org/10.1016/j.compbiolchem.2007.10.003
License
Copyright (c) 2024 Gulnora Muhammadkhan kizi Umarkhodzhayeva, Zafar Isomiddinovich Sanoev
This work is licensed under a Creative Commons Attribution 4.0 International License.
