STRUCTURAL MECHANISMS OF DISTURBANCES IN POSTNATAL MORPHOGENESIS OF THE IMMUNE SYSTEM ORGANS OF THE OFFSPRING BORN UNDER CONDITIONS OF THYROID HYPOFUNCTION IN THE MOTHER

Abstract

The purpose of this study was to identify the structural and functional features of the postnatal development of the organs of the immune system of the offspring obtained under conditions of experimental hypothyroidism of pregnant women in the mother.

The experiments were carried out on rat pups obtained from healthy females and obtained from females with experimental hypothyroidism.

Studies have shown that maternal hypothyroidism leads to a disruption in the process of postnatal growth and formation of the immune system organs in offspring, the morphological manifestation of which is a decrease in the areas of the thymus cortex and T-dependent zones of the lymph nodes and spleen compared to the control, a decrease in proliferative activity and an increase in apoptosis T -lymphocytes both in the thymus and in T-dependent zones of peripheral immune organs.

The mechanism of disturbances in the postnatal development of immune organs is based on an imbalance between the processes of apoptosis and proliferation of lymphoid cells, caused by a deficiency of thyroid hormones in the mother.

Keywords

maternal hypothyroidism, offspring, postnatal ontogenesis, thymus, lymph nodes, spleen