Rheumatoid arthritis (RA) is a disease characterized by joint inflammation and an increased risk of cardiovascular diseases (CVDs). This study examines possible associations between cardiovascular disease and the utilisation of conventional disease-modifying anti-rheumatic drugs (DMARDs) in patients with RA. MTX and SSZ with the latter to lesser extent were associated with a significant reduced risk of CVD than patients with RA who never used either of the drugs or combinations. This study suggests that the use of DMARD, in particular the use of MTX, results in potent suppression of joint inflammation. It also can reduce the development of atherosclerosis and associated CVDs.

RA, CVD, risk

Ziyadullaev SK, Sultonov II, Dushanova GA, Akbarovna KS. The Effectiveness Of Pharmacotherapy For Dmards With Ra Depending On The C3435t Polymorphism Of The Mdr1 Gene. Int. J. of Aquatic Science. 2021 Jun 1;12(3):2908-16.

Panoulas, V. F., Douglas, K. M., Milionis, H. J., et al. (2007). Prevalence and associations of hypertension and its control in patients with rheumatoid arthritis. Rheumatology, 46(9), 1477-1482.

Абдушукурова К, Султонов И. Ревматоид артрит касаллигида денситометрия текширувининг остеопороз диагностикасидаги аҳамияти. Журнал вестник врача. 2018 Oct 3;1(4):12-5.

Ravshanova MS, Ibragimov KI. EFFECTIVENESS OF TRANSVAGINAL ULTRASOUND IN DIAGNOSIS OF ECTOPIC PREGNANCY. InINTERNATIONAL SCIENTIFIC CONFERENCE" INNOVATIVE TRENDS IN SCIENCE, PRACTICE AND EDUCATION" 2022 Sep 10 (Vol. 1, No. 2, pp. 114-115).

Pappas, D. A., Nyberg, F., Kremer, J. M., Lampl, K., Reed, G. W., Horne, L., ... & Greenberg, J. D. (2018). Prevalence of cardiovascular disease and major risk factors in patients with rheumatoid arthritis: a multinational cross-sectional study. Clinical rheumatology, 37(9), 2331-2340.

Aralov NR, ZIYADULLAYEV S, Dushanova GA. Hla-copd and bronchial asthma markers: Commonalities and differences. International Journal of Pharmaceutical Research. 2020 Jan;12(1):1233-7.

Султонов ИИ, Ахмедов ИА. ОСОБЕННОСТИ МЕТАБОЛИЧЕСКОГО СИНДРОМА И ПОРАЖЕНИЙ ПОЧЕК ПРИ ПОДАГРЕ. InInternational scientific review of the problems of natural sciences and medicine 2019 (pp. 354-362).

Sarmiento-Monroy, J. C., Amaya-Amaya, J., Espinosa-Serna, J. S., Herrera-Díaz, C., Anaya, J. M., & Rojas-Villarraga, A. (2012). Cardiovascular disease in rheumatoid arthritis: a systematic literature review in Latin America. Arthritis, 2012.

Wasko, M. C., Kay, J., Hsia, E. C., & Rahman, M. U. (2011). Diabetes mellitus and insulin resistance in patients with rheumatoid arthritis: risk reduction in a chronic inflammatory disease. Arthritis care & research, 63(4), 512-521.

Иргашева У. З., Тоиров Э. С., Ахмедов И. А. Электрокардиографические изменения у больных артериальной гипертонией женщин пери и постменопаузального возраста //Академический журнал Западной Сибири. – 2012. – №. 1. – С. 10-10.

Maradit‐Kremers, H., Nicola, P. J., Crowson, C. S., Ballman, K. V., & Gabriel, S. E. (2005). Cardiovascular death in rheumatoid arthritis: a population‐based study. Arthritis & Rheumatism, 52(3), 722-732.

England, B. R., Thiele, G. M., Anderson, D. R., & Mikuls, T. R. (2018). Increased cardiovascular risk in rheumatoid arthritis: mechanisms and implications. Bmj, 361.

Libby, P. (2008). Role of inflammation in atherosclerosis associated with rheumatoid arthritis. The American journal of medicine, 121(10), S21-S31.

Cavagna, L., Boffini, N., Cagnotto, G., Inverardi, F., Grosso, V., & Caporali, R. (2012). Atherosclerosis and rheumatoid arthritis: more than a simple association. Mediators of inflammation, 2012.

Œwierkot, J., & Szechiñski, J. (2006). Methotrexate in rheumatoid arthritis. Pharmacological reports, 58(473), 473-492.

Kh I, Sultonov I, Islamova K, Axmedov I, Baysariyev S. The Risk of Cardiovascular Disease in Patients with Rheumatoid Arthritis Treated with Conventional DMARDs: a Clinic Based Case Control Study.

Aletaha, D., & Smolen, J. S. (2002). The rheumatoid arthritis patient in the clinic: comparing more than 1300 consecutive DMARD courses. Rheumatology, 41(12), 1367-1374.

Mikuls TR, O‘Dell J. The changing face of rheumatoid arthritis therapy: results of serial surveys. Arthritis Rheum 2000; 43: 464–5.

Ravshanova MS, Ibragimov KI. COMMON RISK FACTORS FOR ECTOPIC PREGNANCY IN YOUNG ADULTS: CLINIC-BASED CASE CONTROL STUDY. InINTERNATIONAL SCIENTIFIC CONFERENCE" INNOVATIVE TRENDS IN SCIENCE, PRACTICE AND EDUCATION" 2022 Sep 10 (Vol. 1, No. 2, pp. 106-107).

Naranjo, A., Sokka, T., Descalzo, M. A., Calvo-Alén, J., Hørslev-Petersen, K., Luukkainen, R. K., ... & Pincus, T. (2008). Cardiovascular disease in patients with rheumatoid arthritis: results from the QUEST-RA study. Arthritis research & therapy, 10(2), 1-10.

Ravshanova M, Ibragimov K. PREDICTORS OF POSTPARTUM HEMORRHAGE IN VAGINAL DELIVERIES: RETROSPECTIVE OBSERVATIONAL STUDY. Results of National Scientific Research International Journal. 2022 Sep 10;1(6):617-26.