In the article, experiments were carried out on white mice on normobaric, hemic and cytotoxic methods of acute hypoxia when administered orally at a dose of 10; 30 and 60 mg/kg dry grape seed extract under normal conditions. According to the results obtained, the obtained extract showed high antihypoxic activity compared with the control group and the reference drug mildronate.

The effect of 1-aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline psychopharmacological activity on the duration of sleep, which was induced with sodium etaminal, on the duration of catalepsy, which was induced with the help of haloperidol, an anti-anxiety, antidepressant activity, was studied. and obtained the necessary conclusions.

Discogenic radiculopathy is the most severe form of degenerative-dystrophic lesion of the spine, which is based on disc degeneration with subsequent involvement of adjacent vertebral bodies, intervertebral joints, and ligamentous apparatus [2,8]. So far, there are many unresolved questions in the etiology and pathogenesis of this disease. Despite the progress in understanding the pathomorphology and clinic of discogenic radiculopathy, the search for pathogenetic, and, therefore, highly effective treatment has not been completed [4,15].

Today, in the practice of a neurologist, the definition of lumbosacral radiculopathy (RCR) is widespread as a nosology characterized by damage to the nerve roots at the lumbosacral level with damage to the intervertebral discs (IVD) and joints of the spinal motion segments (SDS), ligamentous and muscular apparatus with the formation compression-ischemic and concomitant muscular-tonic syndromes caused by functional overstrain of organs and systems.

In this paper, in accordance with the international trend, the term “chronic lumbar radiculopathy” refers to chronic pain in the lumbar region of non-visceral etiology.

147 patients (147 eyes) with age-related cataracts were studied. The density of the lens on the Pentacam system was determined for all patients. We compared the power of the applied force of ultrasound and the equivalent time of its use for five degrees of lens density. The study proved that the PentacamHR's shampflug camera is a fairly accurate method for determining the density of cataracts before surgery, the main advantage of which is its non-contact.

Vertebrogenic lumbosacral radiculopathy, being a global problem of modern healthcare, occupies one of the leading places among the reasons for visiting doctors of various specialties and disability of people of different age categories. According to modern scientific medical research by a number of authors, an episode of back pain, at least once in a lifetime, is noted by 100% of the able-bodied population of developed countries.

The high urgency of the problem of degenerative changes in the spine in the lumbar region is determined by neurological manifestations, changes in psychological and personal characteristics, and a decrease in the quality of life, which attracts close attention of the scientific and medical communities. In particular, it is associated with the peculiarities of the course of the disease, the high frequency of exacerbations and the occurrence in people of the most able-bodied age, unsatisfactory results of treatment and rehabilitation measures, the transformation of the pain syndrome into a chronic form and progressive disability.

According to the literature, from 60% to 80% of the population in industrialized countries experience pain of varying intensity in the lower back against the background of dorsopathy, whose share in the formation of neurological syndromes reaches 95%, and pain, including discogenic origin, is considered the most obligate symptom. , occurring in every fifth person over 30 years of age. In the development and progression of dorsopathies, a significant role is given to the disruption of microcirculation processes, which are observed at the stage of clinically developed manifestations both locally - at the level of the affected segment, becoming one of the factors causing acute pain syndrome, and systemically - in the reflex zones and the central nervous system (CNS) , leading to the preservation, deterioration and chronicity of pain in the conditions of transformation of tissue homeostasis, sensitization and functional dissonance of the CNS structures at different levels, determining the formation of negative pain experience and negative psycho-emotional reactions. A large number of authors indicate degenerative lesions and changes in the musculoskeletal apparatus of the spinal column as the main causes of pain in dorsopathy.