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| Open Access |
DOI:
https://doi.org/10.37547/supsci-ojmp-02-04-02
SCREENING STUDY OF NEUROTROPIC PROPERTIES OF NEW TRIAZOLE DERIVATIVE
S.D. Rakhimboev , Basic doctoral student Institute of Plant Chemistry named after S.Yu. Yunusov of the Academy of Sciences of the Republic of Uzbekistan Tashkent, Uzbekistan Z.I. Sanoev , PhD, Senior Researcher S.Yu. Yunusov Institute of Plant Chemistry of the Academy of Sciences of the Republic of Uzbekistan Tashkent, Uzbekistan T.T. Khamroev , Basic doctoral student Institute of Plant Chemistry named after S.Yu. Yunusov of the Academy of Sciences of the Republic of Uzbekistan Tashkent, Uzbekistan S.Z. Rashidov , Junior Researcher S.Y. Yunusov Institute of Plant Chemistry of the Academy of Sciences of the Republic of Uzbekistan Tashkent, Uzbekistan I.T. Abdinazarov , Basic doctoral student Institute of Plant Chemistry named after S.Yu. Yunusov of the Academy of Sciences of the Republic of Uzbekistan Tashkent, Uzbekistan D.S. Ismailova , PhD, Senior Researcher S.Yu. Yunusov Institute of Plant Chemistry of the Academy of Sciences of the Republic of Uzbekistan Tashkent, Uzbekistan B.J. Elmuradov , Doctor of Chemical Sciences, professor S.Yu. Yunusov Institute of Plant Chemistry of the Academy of Sciences of the Republic of Uzbekistan Tashkent, UzbekistanAbstract
In this article, as a continuation of scientific research on the study of the neurological activity of newly synthesized compounds, the results of studies of the neutropic activity of the 1,2,4 triazole derivative are presented. At the same time, the motor and search activity of compound D-378 was studied in the study conditions, the effect on M-cholinergic receptors in the arecoline tremor method, the effect on catalepsy with haloperidol, and anxiolytic activity. Studies have shown that the compound D-378 exhibits m-cholinomimetic and anxiolytic activity, and also increases the motor and search activity of animals without affecting the catalepsin of gloperidol. This, in turn, requires extensive scientific studies of other neurological activities of the D-378 compound.
Keywords
arecoline tremor, motor activity, research activity
References
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Copyright (c) 2022 S.D. Rakhimboev, Z.I. Sanoev, T.T. Khamroev, S.Z. Rashidov , I.T. Abdinazarov, D.S. Ismailova, B.J. Elmuradov
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