STUDY OF THE HEPATOTROPIC ACTIVITY OF SAFOROFLAVONOLOSIDE UNDER EXPERIMENTAL CONDITIONS

Section: Articles Published Date: 2022-05-24 Pages: 55-64 Views: 14 Downloads: 24

Authors

  • A.N. Aripov Doctor of Medical Sciences, Professor Republican Specialized Pediatric Research and Practice Medical Center Tashkent, Uzbekistan
  • O.A. Aripov Doctor of Medical Sciences, Senior Research Fellow Republican Specialized Pediatric Research and Practice Medical Center Tashkent, Uzbekistan
  • L.L. Akhundjanova Candidate of Biological Sciences, Senior Research Fellow Republican Specialized Pediatric Research and Practice Medical Center Tashkent, Uzbekistan
  • A.U. Nabiev Junior Research Fellow Republican Specialized Pediatric Research and Practice Medical Center Tashkent, Uzbekistan
  • S.Z. Nishonboev Doctor of Chemical Sciences S.Yu. Yunusov Institute of Plant Chemistry Tashkent, Uzbekistan
  • D.A. Nabieva Doctor of Medical Sciences, Senior Research Fellow Republican Specialized Pediatric Research and Practice Medical Center Tashkent, Uzbekistan
  • D.I. Akhmedova Doctor of Medical Sciences, Professor Republican Specialized Pediatric Research and Practice Medical Center Tashkent, Uzbekistan
  • T.T. Khamroev Junior Research Fellow S.Yu. Yunusov Institute of Plant Chemistry Tashkent, Uzbekistan
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Abstract

The effect of the flavonoid glycoside sophoraflavonoloside isolated from the petals of the Crocus sativus L plant (Saffron seed) on hepatoprotective, choleretic and approximate motor activity in chronic liver damage with heliotrin when administered orally at a dose of 100 mg / kg under experimental conditions was studied. The results obtained on the basis of the conducted studies were compared with the control group and the most active dose of the comparative drug Karsil at a dose of 50 mg/kg. Based on preliminary research results, it was found that Soforaflavonoloside does not lag behind karsil and even slightly surpasses a comparable drug in hepatoprotective and choleretic properties. This suggests that the substance under study requires a more extensive in-depth study of the effect of sophoraflavonoloside on the normal and impaired functioning of the liver.

Keywords

hepatotropic activity, choleretic, the “open square